Most Effective Over The Counter Weight Loss Supplement – Medically Reviewed by Zara Risoldi Cochrane, Pharm.D., M.S., FASCP – Written by Jenna Fletcher – Updated July 27, 2023
There is no scientific evidence that Hydroxycut is effective. Side effects can include serious medical problems such as liver disease.
Most Effective Over The Counter Weight Loss Supplement

When trying to lose weight, many people look to supplements for a quick and easy solution. Weight loss supplements, including Hydroxycut, often claim to provide dramatic results in a short period of time.
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However, as with any weight loss supplement, one must question whether or not it works. Find out in this article if Hydroxycut has any effect on people’s weight loss goals. We also look at possible side effects.
Hydroxycut is a brand of weight loss supplement that claims to help a person lose weight quickly.
Hydroxycut is available in various forms such as capsules, drink mixes and gummies. The company offers a variety of Hydroxycut products, including:
All Hydroxycut products are designed to help a person lose weight. The most common ingredient is caffeine. The rest of the ingredients contain various essences and minerals.
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Although caffeine can increase a person’s heart rate and energy level and help reduce appetite, the effects are short-lived.
Early studies in the 1980s and 90s showed some promise, but current evidence does not suggest that caffeine is an effective solution for weight loss.
Hydroxycutin’s website says scientific studies support the claims that their products work, but other sources show mixed results.

This ingredient was found to help with weight loss, but the effect was small. The researchers also stressed that more rigorous and large-scale trials are needed to determine its effectiveness.
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Hydroxycutin’s main ingredient suggests it may have some positive effects on weight loss, but clinical trials are of poor quality.
Even people who participated in clinical trials and lost weight while consuming caffeine did not rely solely on the supplement. They followed an exercise program and a low-calorie diet at the same time.
At the time, Hydroxycut contained ephedra, and the company had to change the formula to remove this ingredient.
Between 2004 and 2009, the most common ingredients in Hydroxycut products were caffeine, green tea extract, and varying amounts of botanical extracts.
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, the FDA recalled Hydroxycut products based on allegations of health fraud. By that time, the FDA had received more
Hydroxycut warns that people under the age of 18 should not use their products. It also warns that a person should stop using the product if they experience any side effects.
Hydroxycut may offer some weight loss benefits due to its caffeine content, but there is no reliable evidence to support this.

People should be aware that Hydroxycut has a questionable track record when it comes to safety. Before starting Hydroxycut, a person should talk to their doctor about how it may affect their overall health or interact with other medications or supplements.
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Medical News Today follows strict purchasing guidelines and relies only on peer-reviewed studies, academic research institutions, medical journals and associations. We avoid using third-level references. We link to primary sources (including research, scientific references and statistics) in each article and list them in the sources section at the bottom of the articles. You can learn more about how we ensure our content is accurate and up-to-date by reading our Editorial Policy. Medically reviewed by Jared Meacham, Ph.D., RD, CSCS – Written by Trista Chan, MHSc RD and Cara Rosenbloom – Updated February 23, 2024
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Probiotics can help with weight loss. Some of the best probiotic supplements for weight loss can vary based on probiotic strain, price, shelf life, and third-party testing.
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All brands and products on our list have been reviewed and verified by registered dietitians to ensure they meet the brand’s standards of integrity and approach to health. Each product in this article:
Below are general price ranges with dollar signs ($-$$$). One dollar sign means the product is more of a bargain, three dollar signs indicate a higher price.
Prices typically range from $0.97 to $2.00 per serving or $42 to $60 per container, although this can vary depending on where you buy it.
Mindbodygreen Probiotics+ contains the probiotic strain Bifidobacterium lactis B420 and is a trademark of DuPont, a chemical and technological innovation company.
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A daily intake of 10 billion CFU of Bifidobacterium lactis B420 was shown to help control body fat, reduce waist size and reduce food intake over 6 months.
People who took this strain for 45 days were found to lose more weight than those who did not.
This probiotic is gluten-free, vegan and shelf-stable. Additionally, Mind BodyGreen notes that the product has been third-party tested for purity and potency, although the testing organization has not been named.
Bariatric Advantage is a sustainable dietary supplement that uses a probiotic strain of the Bifidobacterium lactis B420 brand that has been specifically studied.
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Although not refrigerated, FloraVantage Control should be stored below 75°F (24°C). Therefore, it is important to buy from a trusted retailer to ensure that the product is stored and delivered at the correct temperature.
Bariatric Advantage supplements are manufactured in cGMP compliant facilities. However, the products are not third-party tested to confirm purity and effectiveness.
A study funded by Cultech Ltd., a manufacturer of dietary supplement ingredients, clinically tested the probiotic strains used in Genestra Brands HMF Metabolic.
Overweight or obese subjects who took probiotic supplements containing 50 billion CFU of Lactobacillus acidophilus CUL60 and CUL21, Lactobacillus plantarum CUL66, Bifidobacterium bifidum CUL20 and Bifidobacterium animalis subsp. lactis CUL34 weight, lower body mass index and smaller waist measurement after 6 months compared to placebo patients.
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In the study above, people were given probiotic supplements with 10 billion CFU, which is higher than the 2 billion found in Culturelle Metabolism + Weight Management. Therefore, it is not known if this supplement contains an effective dose.
Although Culturelle’s products are not routinely tested for purity and potency in a third-party lab, the company says it takes several steps to ensure quality and safety.
RenewLife Healthy Weight 2-in-1 Prebiotics + Probiotics contains Lactobacillus gasseri BNR17 and Lactobacillus rhamnosus, two probiotic strains that have been studied for weight management.
Overweight or obese adults who consumed 10 billion CFU of L. gasseri BNR17 for 12 weeks had significantly lower visceral fat and waist circumference than those who did not.
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Another study found that obese women who consumed L. rhamnosus CGMCC1.3724 experienced significant weight and fat loss after 12 weeks of dietary changes. These changes persisted after 24 weeks. Interestingly, the probiotic had no significant effect on men.
It is important to note that although RenewLife Healthy Weight 2-in-1 Prebiotics + Probiotics contains L. rhamnosus, it does not indicate if it is the CGMCC strain.
Renew Life Healthy Weight 2-in-1 Prebiotics + Probiotics is dairy-free, but not certified vegan. Also, it’s not stable so you have to refrigerate it.
L. Gasseri BNR17, f. Lactis, L. plantarum, L. Acidophilus, L. Paracasey, S. thermophilus, L. Casey, L. Rhamnosus, B. Bifidum, B. long
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The mechanisms by which these probiotic strains affect body weight are not well understood, but they are believed to reduce inflammation by regulating the gut microbiome.
When purchasing probiotics for weight loss, it’s important to look for one of the above strains.
While they may be good for general gut health support, most broad-spectrum probiotics do not contain specific strains that have been shown to be effective for weight loss.
For example, a probiotic supplement may list Lactobacillus rhamnosus as an ingredient. However, there are many strains of L. rhamnosus, and only L. rhamnosus CGMCC1.3724 has been shown to be effective for weight loss.
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It is impossible to know by looking at the label if the product in question contains the right strain for weight loss.
When purchasing a probiotic for your weight loss, it’s important to consider several factors, including your nutritional needs and the product’s probiotic strains, CFU count, storage requirements, third-party testing, and cost.
Be sure to choose a product that contains a probiotic strain that has been shown to be effective in weight management.
The Clinical Guide to Probiotic Products is a handy reference that lists brands of clinically tested probiotic strains and their intended uses.
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In addition to containing an evidence-based strain, weight loss probiotics should contain an effective dose of that strain.
For example, Bifidobacterium lactis B-420 has been shown to be effective at doses of 10 billion CFU per day.
Weight loss studies using Lactobacillus acidophilus CUL-60, Lactobacillus acidophilus CUL-21, Lactobacillus plantarum CUL-66 and Bifidobacterium animalis subsp. lactis CUL-34 and Bifidobacterum bifidum CUL-20 are effective
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