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When fat blocker Eli hit pharmacy shelves last June, hopeful consumers signed up for the first government-approved over-the-counter weight-loss drug. But it didn’t take long, and the lack of real weight loss for some convinced many dieters that Eli wasn’t the only answer to their weight problems.

Besides Eli, there are about six other prescription weight loss drugs on the market. Some, like Eli, inhibit the absorption of fat in the body. Others work on the brain to suppress appetite. But the reality is that no matter how many diet pills you take, they don’t work by themselves.

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“The pills we have right now don’t seem to be very effective for long-term weight loss,” says Ann Fletcher, a registered dietitian in Mankato, Minn. “When people go off pills, many gain weight.”

Still, the pharmaceutical industry and many nutritionists remain convinced that the pill is the answer to the nation’s growing obesity epidemic. Several new, including the experimental drug lorcaserin, a form of pan-pan. At least 30 companies are developing drugs for weight loss, and experts estimate that 10 to 15 drugs will be developed in the coming years to help thin people in different ways. Pharmaceutical research company Decision Resources predicts that the market for obesity drugs in the United States will grow from $222 million in 2006 to nearly $2 billion in 2016.

Research suggests that combined with diet and exercise, obesity medications can help a person lose 5 to 10 percent of excess weight. However, because different pills affect the body in different ways, it is possible that some people may be better off using one type of pill over another. 

For example, one study looking at the differences between sibutermin (Meridia) and orlistat (Xenical Valley) found that greater weight loss with orlistat occurred in people who could be described as “conscientious,” that is, their personalities were more organized. – were chief or targeted. So strict monitoring of fat intake works for them. People who have trouble controlling their eating habits have seen a greater effect with sibutramine – which affects serotonin in the brain and makes you feel full before you eat.

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Generally, the biggest mistake people make when taking diet pills is mistaking them for magic pills.

“People can’t expect a drug to do it for them,” says Gary Foster, director of the Center for Obesity Research and Education at Temple University in Philadelphia. “It’s a 50/50 partnership with the pill as half of the equation. Exercise, what we eat and our lifestyle habits…are critical to long-term success.”

When clients ask about using a dietary supplement, Fletcher, author of “Thin for Life,” tells them to think of it as “one leg on a four-legged stool.”

“One leg is exercise; one is diet; one is behavior change and the last leg might be diet pills,” she says. “Take out each of the legs supporting the diet pill and the stool will fall.” 

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From his research, Fletcher found that people who lost significant amounts of weight took several attempts to lose weight before realizing long-term success.

“When we try to change behavior, it takes most of us some effort to make it happen,” she says.

There is no real data on how long the pills are safe, especially for young people. However, the Food and Drug Administration has only approved them for adults for up to two years of continuous use. According to an analysis of 30 studies of adults who took anti-obesity drugs for one to four years, about 30 to 40 percent stopped taking them after a year, though it was not clear why.

In addition, side effects are common. Sibutramine may increase blood pressure and heart rate in some patients. Orlistat, which alters the absorption of fat in food, can have embarrassing side effects in the intestines. Rimonabant (used in Europe but awaiting approval in this country) can cause nausea, anxiety, depression and insomnia in some users.

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But for obese people — those with a body mass index of 30 or higher — the benefits of prescription diet drugs may outweigh the risks, experts say.

“The most successful people are those who are committed to losing weight and willing to take responsibility for their actions and change,” says Pat Baird, a diet and nutrition consultant in GlaxoSmithKline’s consumer health division who works as an online is, says A guide for people using Ali. She talks to 25 people a day, showing questions about weight loss, the plan and the pill.

Baird admits that the reason Eli works for some people has side effects. When a person eats more than the prescribed 15 grams of fat per meal, they may experience digestive problems. “It helps keep people honest,” she says. It is the fourth drug approved in Israel to help people with severe weight problems.

Melbourne physiologist Professor Michael Cowley developed the drug while working overseas after mapping key brain regions involved in regulating food intake.

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Naltrexone and bupropion are two ingredients now used separately in drugs to help curb drug use and stop smoking.

“We found that there are two places where these two drugs can have an effect on appetite, to reduce appetite, but also an effect on something called the reward center to reduce the desire for food. put,” he said.

Along with reduced calorie diet and increased exercise, the effects of Contrave on weight loss have been the subject of several trials.

In one study, a weight loss of at least 5 percent from baseline body weight was observed in patients treated with Contrav, compared with placebo.

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“Weight loss doesn’t change people’s appearance, but it does improve metabolic health,” Professor Cowley said.

This includes reducing the risk of heart attack and reducing the risk of diabetes and cholesterol conditions, he said.

The most common side effects observed in the study were nausea, vomiting and constipation, and there was a very low risk of seizures and suicidal thoughts.

People taking the drug are told to stop after 16 weeks, if they haven’t lost at least 5 percent of their original body weight.

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Obesity expert Professor John Dixon says the addition of Contrave gives doctors another chance to treat more people correctly.

He said the 1.5 million Australians who are chronically obese are not being treated effectively and often blame a lack of willpower.

Contrave should only be taken for a maximum of 16 weeks as it has some side effects. ()

“You have to take the drug continuously and I don’t think we know enough about the long-term use of these drugs,” said Professor Gary Wittert, medical director at the University of Adelaide.

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“Drugs may have a place in specific situations where extra help is needed,” Professor Wittert said. “But I don’t think we can be honest enough about who will benefit most and under what circumstances.” in,” said Professor Wittert.

In Australia, Contrave is indicated for adults who are overweight or have metabolic conditions caused by obesity. Zara Risoldi Cochrane, Pharm.D., MS., F.A.S.C.P. Clinically reviewed by – Written by Jenna Fletcher – Updated July 27, 2023

Scientific evidence for the effectiveness of Hydroxycut is lacking. Side effects can include serious medical concerns, such as liver disease.

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